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. Author manuscript; available in PMC: 2021 Nov 9.
Published in final edited form as: Ann N Y Acad Sci. 2020 Nov 9;1480(1):246–256. doi: 10.1111/nyas.14525

Figure 6.

Figure 6.

Anti-TNF-α antibody blunts NM-induced decreases in lung volume and respiratory area. (A) Total lung volume at 1, 3, 7, and 28 d post exposure was calculated from the lung CT analysis by summarizing areas under the curve of air, tissue, and fluid radiodensities. Total lung volume was subtracted from mean pre-exposure total lung volume to determine the change in total lung volume. Data are mean ± SE (n = 6–8 rats/treatment group/time point). (B) 3D rendering of rat lung respiratory area used to quantify changes corresponding to air in the lung at days 1 and 28 after exposure of rats to CTL (n = 6), NM (n = 6), or NM + anti-TNF-α antibody (n = 8). Areas of lung that are absent reflect hemorrhage, edema and/or consolidated tissue. One representative 3D rendering is shown.