Table 2.
Diagnostic performance and diagnostic certainty of CAST using a panel of reference sera.
| CAST device | RT- PCR SARS-CoV-2 |
Positive percent agreement (PPA) (95% CI) |
Negative percent agreement (NPA) (95% CI) |
Overall percent agreement (95% CI) |
Kappa (95% CI) |
|||
|---|---|---|---|---|---|---|---|---|
| Positive | Negative | Total | ||||||
| CAST IgM | Positive | 35 | 4 | 39 | 97.2% (84.6–100.0) | 94.4% (86.2–98.2) |
95.4% (89.3–98.3) | 0.898 (0.811–0.985) |
| Negative | 1 | 68 | 69 | |||||
| Total | 36 | 72 | 108 | |||||
| CAST IgG | Positive | 34 | 4 | 38 | 97.2% (84.6–100.0) | 95.8% (88.0–99.1) |
96.3% (90.6–98.9) | 0.918 (0.839–0.997) |
| Negative | 0 | 70 | 70 | |||||
| Total | 34 | 74 | 108 | |||||