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. 2020 Jun 25;69(9):1903–1916. doi: 10.2337/db19-1174

Figure 1.

Figure 1

Circulating 3-HIB is associated with type 2 diabetes and measures of insulin resistance and adiposity in the HUSK cohort. A: Plasma concentrations (adjusted geometric mean ± 95% CI) of 3-HIB and valine in the groups with normoglycemia (n = 4,537), hyperglycemia (n = 204), and established type 2 diabetes (n = 201). The group with hyperglycemia consisted of people with glucose values >7 mmol/L but <11.1 mmol/L. The group with diabetes was based on self-reported diabetes with the addition of a few individuals with nonfasting glucose >11.1 mmol/L. B: Associations for plasma 3-HIB and measures of insulin resistance and adiposity in multivariate models adjusted for age and sex in the groups with normoglycemia (n = 4,761) and hyperglycemia/diabetes combined (n = 405). The combination of the latter groups gave a similar result as for the groups individually but increased statistical power. The group with hyperglycemia/diabetes included participants with self-reported type 2 diabetes and those with nonfasting glucose levels >7 mmol/L. Data are shown as estimates with 95% CI. WHR, waist-to-hip ratio.