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. 2020 Jun 25;69(9):1903–1916. doi: 10.2337/db19-1174

Figure 2.

Figure 2

Circulating 3-HIB is associated with obesity-related insulin resistance and shows dynamic changes after bariatric surgery. A and B: Graphical representation of Spearman correlations for serum 3-HIB and valine concentrations and measures related to insulin resistance in 85 people ranging in BMI from 18 to 57 kg/m2 (WNOB-1 cohort). A: Correlations are significant for Spearman ρ <−0.22 and >0.22 (indicated by dashed lines). B: The correlations were adjusted for all variables shown in addition to age and sex. Green and red lines indicate positive and negative correlations, respectively, and line thickness the strength of correlation. C: Serum concentrations of 3-HIB and valine in patients with obesity pre– and 1 year post–bariatric surgery. Data are presented as mean ± SEM (t test) (WNOB-1 cohort). D: Individual serum concentrations of 3-HIB and valine in patients with obesity before, 1 week post–, and 1 year post–bariatric surgery (Roux-en-Y gastric bypass or laparoscopic sleeve gastrectomy) (WNOB-2 cohort). The black line indicates mean levels and gray lines individual levels. H2-B, HOMA2 of β-cell function; H2-IR, HOMA2-IR; Pre, before bariatric surgery; Val, Valine. **P < 0.01; ***P < 0.001.