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. 2021 Mar 2;9:642737. doi: 10.3389/fcell.2021.642737

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Copyright © 2021 Yadav and Claeys Bouuaert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DSB formation in S. cerevisiae. (A) The distribution of meiotic DSBs is influenced by a combination of factors that operates at various size scales (Pan et al., 2011). Spo11 footprint indicates the expected occupancy of Spo11 on DNA based on structural modeling. (B) The tethered loop-axis model for DSB formation. Spp1 binds to H3K4me2/3 enriched around DSB hotspots and connects it to the chromosome axis through interaction with Mer2. Axis proteins Red1 (red ovals) and Hop1 (yellow ovals) are shown. (C) Ten DSB proteins in S. cerevisiae.