Table 2.
Methodological quality of included trials
| Trial identifier | Estimated sample size | Allocation (randomized/non-randomized) | Blinding/masking | Study design |
|---|---|---|---|---|
| NCT04438980 | 72 | Randomized | Double | Interventional |
| NCT04435795 | 454 | Randomized | Triple | Interventional |
| NCT04425863 | 10 | Not available | Not available | Non-interventional, prospective cohort |
| NCT04416399 | 478 | Randomized | Open label | Interventional |
| NCT04411667 | 40 | Randomized | Open label | Interventional |
| NCT04395105 | 284 | Randomized | Open label | Interventional |
| NCT04394182 | 15 | Not available | Open label | Interventional |
| NCT04381936 | 12000 | Randomized | Open label | Interventional |
| NCT04348305 | 1000 | Randomized | Quadruple | Interventional |
| NCT04331054 | 436 | Randomized | Open label | Interventional |
| NCT04360876 | 90 | Randomized | Double | Interventional |
| NCT04355247 | 20 | Not available | Open label | Interventional |
| NCT04381364 | 446 | Randomized | Open label | Interventional |
| NCT04380818 | 106 | Non-randomized | Open label | Interventional |
| NCT04377711 | 400 | Randomized | Double | Interventional |
| NCT04377503 | 40 | Randomized | Open label | Interventional |
| NCT04374474 | 75 | Randomized | Open label | Interventional |
| NCT04366115 | 126 | Randomized | Open label | Interventional |
| NCT04361474 | 120 | Randomized | Single | Interventional |
| NCT04359511 | 210 | Randomized | Single | Interventional |
| NCT04355637 | 300 | Randomized | Open label | Interventional |
| NCT04349410 | 500 | Randomized | Single | Interventional |
| NCT04347980 | 122 | Randomized | Single | Interventional |
| NCT04263402 | 100 | Randomized | Single | Interventional |
| NCT04193878 | 600 | Randomized | Triple | Interventional |
| NCT03852537 | 90 | Randomized | Double | Interventional |
| NCT02735707 | 7100 | Randomized | Open label | Randomized, multifactorial trial |
| NCT04345445 | 310 | Randomized | Open label | Interventional |
| NCT04344730 | 550 | Randomized | Quadruple | Interventional |
| NCT04344288 | 304 | Randomized | Open label | Interventional |
| NCT04343729 | 425 | Randomized | Quadruple | Interventional |
| NCT04341038 | 84 | Randomized | Single | Interventional |
| NCT04331470 | 30 | Randomized | Double | Interventional |
| KCT0005105 | 141 | Randomized | Open label | Interventional |
| NCT04329650 | 200 | Randomized | Open label | Interventional |
| NCT04327401 | 350 | Randomized | Open label | Interventional |
| NCT04325061 | 200 | Randomized | Open label | Interventional |
| NCT04323592 | 173 | Non-randomized | Open label | Non-interventional, prospective cohort |
| NCT04374071 | 250 | Non-randomized | Not available | Non-interventional, retrospective cohort |
| NCT04244591 | 80 | Randomized | Open label | Interventional |
| NCT04273321 | 86 | Randomized | Open label | Interventional |
| IRCT20080901001165N52 | 50 | Randomized | Open label | Interventional |
| IRCT20200406046963N1 | 40 | Randomized | Open label | Interventional |
| IRCT20200404046947N1 | 68 | Randomized | Single | Interventional |
| IRCT20081027001411N3 | 60 | Randomized | Single | Interventional |
| IRCT20120215009014N354 | 81 | Randomized | Double | Interventional |
| IRCT20200204046369N1 | 48 | Non-randomized | Open label | Interventional |
| IRCT20200318046812N2 | 906 | Randomized | Open label | Interventional |
| IRCT20151227025726N17 | 48 | Randomized | Open label | Interventional |
| IRCT20120225009124N4 | 105 | Randomized | Open label | Interventional |
| ChiCTR2000029386 | 24 | Randomized | Not available | Interventional |
| ChiCTR2000029656 | 50 | Randomized | Open label | Interventional |
| ChiCTR2000030481 | 75 | Randomized (static) | Not available | Interventional |
| 2020-001827-15 | 72 | Randomized | Double | Interventional |
| 2020-001307-16 | 104 | Randomized | Open label | Interventional |
| 2020-001395-15 | 1000 | Randomized | Double | Interventional |
| 2020-001622-64 | 200 | Randomized | Open label | Interventional |
| 2020-001934-37 | 200 | Randomized | Open label | Interventional |
| 2020-001413-20 | 100 | Randomized | Open label | Interventional |
| 2020-001445-39 | 84 | Randomized | Open label | Interventional |