Table 1. Baseline characteristics of the COVID-19 cohort.
| COVID Cohort (n = 32) | With CAPA (n = 11) | Without CAPA (n = 21) | p value | |
|---|---|---|---|---|
| Baseline characteristics | ||||
| Median age, years (range) | 69.5 (27–84) | 72 (58–84) | 59 (27–84) | 0.065 |
| Male sex (%) | 23 (72) | 7 (63) | 16 (76) | 0.195 |
| Mean APACHE II (SD) | 18±4 | 22±3 | 17 ±3 | <0.001 |
| Mean SOFA (SD) | 10±3 | 12±2 | 9 ±3 | 0.003 |
| Risk factors n (%) | ||||
| COPD | 3 (10) | 2 (18) | 1 (5) | 0.266 |
| Asthma | 1 (3) | 0 (0) | 1 (5) | 1.00 |
| DM type 2 | 8 (25) | 3 (27) | 5 (24) | 1.00 |
| Art. hypertension | 21 (65) | 7 (63) | 14 (66) | 1.00 |
| Coronary heart disease | 2 (6) | 1 (9) | 1 (5) | 1.00 |
| CKD | 5 (16) | 1 (9) | 4 (19) | 0.637 |
| Atrial fibrillation | 5 (16) | 1 (9) | 4 (19) | 0.637 |
| COVID-19 specific characteristics | ||||
| SARS-CoV-2 PCR positive at admission | 32 | 11 | 21 | 0.670 |
| Symptoms before hospital admission, days (SD) | 4± 2 | 3±1 | 4±2 | 0.080 |
| Mean days at general ward, (SD) | 2±2 | 1±2 | 7±2 | 0.510 |
| Number of direct ICU admissions | 20 | 7 | 13 | 0.235 |
| Influenza/RSV PCR negative | 32 | 11 | 21 | - |
| Median days of fever, (range) | 8 (3–12) | 9 (3–15) | 8 (4–13) | 0.260 |
| ICU data | ||||
| Mechanical ventilation | 32 | 11 | 21 | 0.670 |
| Mechanical ventilation days (range) | 16 (3–28) | 20 (8–28) | 15 (3–28) | 0.570 |
| Need for vasopressors (%) | 32 (100) | 11 (34) | 21 (66) | 0.490 |
| Renal replacement (%) | 9/32 (28) | 6/11 (55) | 3/21 (14) | 0.380 |
| Broadspectrum antibiotics | 32 | 11 | 21 | 0.670 |
| Outcome data | ||||
| Median days of ICU stay (range) | 18 (5–28) | 21 (9–28) | 17 (5–28) | 0.222 |
| ICU mortality (%) | 6 (19) | 4 (36) | 2 (9,5) | <0.001 |
| 28 days status: | ||||
| - ICU | 11 | 4 | 7 | 0.145 |
| - Hospital | 5 | 2 | 4 | 0.266 |
| - Discharge | 10 | 1 | 8 | 0.025 |
Abbreviations: COVID-19 associated invasive pulmonary aspergillosis (CAPA), acute physiology and chronic health evaluation (APACHE II); sequential organ failure assessment (SOFA); chronic obstructive pulmonary disease (COPD); diabetes mellitus type 2 (DM type II); chronic kidney disease (CKD); intensive care unit (ICU) standard deviation (SD); polymerase chain reaction (PCR); Intensive Care Unit (ICU); Respiratory Syntactical Virus (RSV).