Table 2. Novel genomic regions with pleiotropic aerodigestive SqCC associations.

Regiona	EA/OAb	Gene	EAF	SqCC site	OR	95%CI	P	ORmeta	95%CImeta	Pmeta c
Genome-wide significant loci
2q33.1	A/G	TMEM237	0.31	Lung	0.92	0.88–0.96	2.51E-04	0.902	0.87–0.94	6.99E-09
rs56321285				Oral/oropharynx	0.89	0.83–0.94	2.34E-04
2:202505545				Larynx	0.79	0.67–0.93	3.83E-03
				Esophagus	0.8	0.64–0.98	3.56E-02
Suggestive loci
1q32.1	G/T	MDM4	0.35	Lung	1.07	1.03–1.11	4.63E-04	1.08	1.05–1.12	2.16E-07
rs12133735				Oral/oropharynx	1.14	1.08–1.21	9.82E-06
1:204556836				Larynx	1.05	0.92–1.20	5.14E-01
				Esophagus	1	0.83–1.19	9.74E-01
5q31.2	G/A	TMEM173	0.28	Lung	1.09	1.05–1.14	5.29E-05	1.09	1.05–1.13	1.74E-07
rs13181561				Oral/oropharynx	1.1	1.04–1.17	1.74E-03
5:138850905				Larynx	1.12	0.96–1.3	1.44E-01
				Esophagus	1.06	0.87–1.3	5.62E-01
19p13.11	A/G	ABHD8	0.3	Lung	1.09	1.05–1.14	2.05E-05	1.09	1.05–1.12	9.86E-08
rs61494113				Oral/oropharynx	1.09	1.03–1.16	4.91E-03
19:17401859				Larynx	1.15	1.00–1.31	5.22E-02
				Esophagus	1.05	0.87–1.27	5.90E-01

^a Lead SNP (lowest P, F-E meta-analysis), regions at P<5x10^-7

^b EA = Effect allele/OA = other allele; EAF = average effect allele frequency between sites.

^c F-E meta-analysis (ASSET) accounting for control overlap between Lung SCC and oral/pharynx analysis and larynx and esophageal analysis.