Two different DWI lesion patterns in patients with hypoglycemic coma are indicative of 2 different outcomes. When focal lesions involving the posterior limb of the internal capsule (eg, patient 4, unilateral lesion, A; patient 9, bilateral lesions, B) were seen, outcomes were good. C and D, However when diffuse lesions involving bilateral hemispheric white matter including the internal capsule, corona radiata, and centrum semiovale (eg, patient 19), were seen, outcomes were poor.