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. 2021 Mar 17;7(12):eabe7520. doi: 10.1126/sciadv.abe7520

Table 2. Effect of covariates on mean MtHz.

The pc values are from principal components analysis. Autosomal variance refers to the variability from homozygosity at autosomal positions. Haplogroup values are compared to haplogroup H (n = 72,363). The number of individuals with each haplogroup is noted.

Covariate Estimate (β) SE t value Pr(>|t|)
Age −0.000246 3.28 × 10−5 −7.5 6.80 × 10−14
Sex, F −0.040726 1.15 × 10−3 −35.3 9.80 ×
10−273
pc.0 0.006926 5.90 × 10−4 11.7 8.00 × 10−32
pc.1 −0.001214 5.80 × 10−4 −2.1 0.036
pc.2 −0.001546 5.80 × 10−4 −2.7 0.0077
pc.3 −0.000978 5.79 × 10−4 −1.7 0.091
pc.4 0.001443 5.82 × 10−4 2.5 0.013
Autosomal
variance
0.640646 8.52 × 10−4 752.3 <×10−300
Hap H1
(203003)
0.000753 2.47 × 10−3 0.3 0.76
Hap. H2
(31389)
0.017434 3.86 × 10−3 4.5 6.10 × 10−6
Hap. H3
(28107)
0.082418 4.01 × 10−3 20.6 6.80 × 10−94
Hap. H4
(15052)
0.047945 5.11 × 10−3 9.4 6.30 × 10−21
Hap. H5
(37219)
0.018601 3.64 × 10−3 5.1 3.20 × 10−7
Hap. H6
(20240)
0.040591 4.53 × 10−3 9 3.40 × 10−19
Hap. HV
(23855)
0.021313 4.26 × 10−3 5 5.80 × 10−7
Hap. J1
(76312)
0.092318 2.96 × 10−3 31.2 1.20 ×
10−213
Hap. J2
(17812)
0.113978 4.77 × 10−3 23.9 3.70 ×
10−126
Hap. K1
(71844)
0.134303 3.02 × 10−3 44.4 <×10−300
Hap. K2
(18034)
0.134744 4.75 × 10−3 28.3 1.10 ×
10−176
Hap. T1
(21921)
0.148079 4.40 × 10−3 33.7 1.10 ×
10−248
Hap. T2
(76650)
0.118618 2.96 × 10−3 40.1 <×10−300
Hap. U2
(12438)
0.134402 5.53 × 10−3 24.3 3.20 ×
10−130
Hap. U4
(23358)
0.122405 4.29 × 10−3 28.5 1.10 ×
10−178
Hap. U5
(84439)
0.120046 2.89 × 10−3 41.5 <×10−300
Hap. V
(17675)
0.009295 4.78 × 10−3 1.9 0.052
Hap. X2
(14869)
0.049903 5.13 × 10−3 9.7 2.50 × 10−22
Hap. Other
(115492)
0.079721 2.71 × 10−3 29.4 1.90 ×
10−190