Table 3.
Univariable | Multivariable † | |||||
---|---|---|---|---|---|---|
IRR | 95% CI | p-value | aIRR | 95% CI | p-value | |
Female gender | 1.09 | 1.06–1.12 | <0.001 | 1.04 | 1.01–1.07 | 0.007 |
Age (at transplant) per year | 1.01 | 1.00–1.01 | <0.001 | 1.01 | 1.00–1.01 | <0.001 |
Race | ||||||
White | Ref | 0.91–0.99 | 0.013 | |||
Black | 0.95 | 1.12–1.23 | <0.001 | |||
Hispanic | 1.17 | 0.99–1.18 | 0.08 | |||
Asian | 1.08 | |||||
Nonwhite race | 1.07 | 1.04–1.11 | <0.001 | |||
Body mass index | 1.00 | 0.99–1.00 | 0.001 | 0.99 | 0.99–1.00 | <0.001 |
Diabetes | 1.04 | 1.01–1.08 | 0.02 | |||
Liver diagnosis | ||||||
Alcohol | Ref | 0.96–1.03 | 0.76 | |||
Hepatitis C | 0.99 | 0.97–1.07 | 0.49 | |||
NASH | 1.02 | 0.92–1.03 | 0.28 | |||
Cryptogenic | 0.97 | 0.94–1.23 | 0.31 | |||
Hepatitis B | 1.07 | 0.87–0.96 | <0.001 | |||
Autoimmune/cholestatic | 0.91 | |||||
Prior transplant | 1.22 | 1.11–1.34 | <0.001 | 1.21 | 1.10–1.33 | <0.001 |
Days on waitlist | 1.00 | 1.00–1.00 | 0.28 | |||
Insurance | ||||||
Private | Ref | 1.09–1.18 | <0.001 | Ref | 1.03–1.11 | 0.001 |
Medicaid | 1.14 | 1.10–1.18 | <0.001 | 1.07 | 1.05–1.12 | <0.001 |
Medicare | 1.14 | 1.09 | ||||
MELDNa at transplant per point | 1.03 | 1.03–1.03 | <0.001 | 1.01 | 1.01–1.01 | <0.001 |
Albumin at transplant per point | 1.13 | 1.10–1.16 | <0.001 | |||
Hepatic encephalopathy | 1.25 | 1.22–1.28 | <0.001 | 1.09 | 1.07–1.12 | <0.001 |
Ascites | 1.08 | 1.03–1.13 | 0.002 | 0.90 | 0.85–0.94 | <0.001 |
Dialysis at transplant | 1.64 | 1.59–1.70 | <0.001 | |||
Life support at transplant | 2.08 | 1.99–2.18 | <0.001 | 1.57 | 1.50–165 | <0.001 |
Portal vein thrombus at transplant | 1.08 | 1.03–1.13 | 0.001 | 1.07 | 1.02–1.11 | 0.002 |
KPS category prior to transplant | ||||||
80 or more | ||||||
50–70 | Ref | Ref | ||||
40 or less | 1.10 | 1.71–1.87 | <0.001 | 1.04 | 1.00–1.09 | 0.07 |
1.79 | 1.71–1.87 | <0.001 | 1.37 | 1.31–1.44 | <0.001 | |
Hospitalization pre-transplant | 1.72 | 1.67–1.77 | <0.001 | 1.21 | 1.16–1.26 | <0.001 |
Transplant from ICU | 1.93 | 1.86–2.00 | <0.001 | 1.24 | 1.18–1.29 | <0.001 |
Donor risk index per point | 0.95 | 0.92–0.99 | 0.006 | 1.04 | 1.01–1.08 | 0.05 |
Adjusted for year and region
Incidence rate ratio (IRR); confidence interval (CI); Nonalcoholic steatohepatitis (NASH); Model for End-Stage Liver Disease with Sodium (MELDNa); Karnofsky Performance Score (KPS); intensive care unit (ICU).