TABLE 1.
The target of EMT‐associated miRNAs in different cancer types
| miRNAs | Cancer types | Direct/indirect targets | Reference |
|---|---|---|---|
| Tumor suppresser miRNAs | |||
| miR‐25‐3p | CC | Sema4C | [106] |
| miR‐26a | LC | EZH2 | [65] |
| miR‐30a/c | OC | DNMT1 | [102] |
| miR‐34a | OC, LC, BC, CRC | Snail, MCTS1, ZNF281 | [49, 51‐53] |
| miR‐99a | LC | E2F2, ADGRE2 | [29] |
| miR‐125b | HCC | Smad2, Samd4, EVA1A | [31, 114] |
| miR‐125a‐3p | PC, EC, PRC | Fyn, STAT3 | [141, 170, 153] |
| miR‐128‐3p | CRC | Bmi1, MRP5 | [165] |
| miR‐129‐5p | BC, LC | MCRS1 | [89, 109] |
| miR‐130a | LC, HCC | Smad4 | [70, 115] |
| miR‐134 | CRC | CREB1 | [126] |
| miR‐137 | OC | Snail | [49] |
| miR‐139‐5p | CRC, NPC | BCL2 | [127, 144] |
| miR‐140 | LC, GBM | CTSB | [86, 152] |
| miR‐145 | CRC | Snail | [32] |
| miR‐146b | LC | PTP1B | [71] |
| miR‐155 | LC, | Smad2 | [87] |
| miR‐195‐5p | CRC | GDPD5, Notch2 | [128, 129] |
| miR‐199a‐5p | BC | PIK3CD | [33] |
| miR‐200 family | OC, HCC, LC, GC, BC, PC | NFATC1, CTSL, LIN28B, ERRFI1 ZEB1, ZEB2, ZNF17 | [48, 54, 55, 85, 171, 172, 81, 98, 133] |
| miR‐203 | RCC, PRC, CRC, PC | PTEN, Slug, ZEB1 | [43, 44, 46, 47] |
| miR‐204 | BC, GC | TGFBR2 | [14, 99] |
| miR‐205 | BC, LC, NPC | Notch2, PTEN | [35, 73, 146] |
| miR‐218 | PRC | Gli1, Slug | [36, 71] |
| miR‐221 | EC | DKK2 | [143] |
| miR‐296‐3p | LC, NPC | PRKCA, MK2 | [74, 145] |
| miR‐363 | OC | Snail | [173] |
| miR‐374a | NPC | CCND1 | [147] |
| miR‐375 | HCC | c‐Myc | [117] |
| miR‐451 | LC | c‐Myc | [75] |
| miR‐452 | BC | Slug | [37] |
| miR‐483‐3p | LC | ITGB3 | [76] |
| miR‐485‐5p | OSCC | PAK1 | [154] |
| miR‐495 | LC | UBE2C | [80] |
| miR‐499a | OS | SHKBP1 | [155] |
| miR‐504 | GBM | FZD7 | [38] |
| miR‐508 | CRC | ZEB1, Bmi1, SALL4 | [98] |
| miR‐574‐3p | GC | ZEB1 | [96] |
| miR‐612 | HCC | AKT2 | [118] |
| miR‐1247 | PRC | NRP1 | [41] |
| miR‐1294 | OC | IGF1R | [103] |
| miR‐3656 | PC | RHOF | [135] |
| miR‐4319 | HCC | FOXQ1 | [42] |
| Let‐7 | OC, LC | ABCC2, Bcl‐xl | [48, 51, 174] |
| Oncogenic miRNAs | |||
| miR‐10b | BC | PTEN, RBICC1 | [57, 58] |
| miR‐15b | LC | PEBP4 | [94] |
| miR‐17 | GC | DEDD | [101] |
| miR‐20a | CC | FBXL5, BTG3 | [64] |
| miR‐21 | LC | HBP1 | [96] |
| miR‐27a | LC, HCC | RKIP | [95, 175] |
| miR‐32‐5p | HCC | PTEN | [120] |
| miR‐106b cluster | BC | EP300 | [113] |
| miR‐124 | CRC | PRRX1 | [132] |
| miR‐134 cluster | LC | MAGI2 | [93] |
| miR‐155 | LC, GC, BC | RHOA, GATA3, P53INP1, FOXO‐3a | [88, 161, 164] |
| miR‐196a | HCC | NA | [176] |
| miR‐210 | BC | E‐cadherin, Snail | [59] |
| miR‐221 | PC | SOCS3 | [140] |
| miR‐233 | HCC | Fbw7 | [121] |
| miR‐296‐5p | PC | BOK | [138] |
| miR‐495 | LC | ETK | [79] |
| miR‐577 | GC | CAVIN2 | [60] |
| miR‐5188 | HCC, BC | FOXO1 | [62, 63] |
Abbreviations: BC, breast cancer; CC, cervical cancer; CRC, colorectal cancer; EC, esophageal cancer, GC, gastric cancer; GBM, glioblastoma; HCC, Hepatic carcinoma; LC, lung cancer; PC, pancreatic cancer; PRC, prostate cancer; NPC, nasopharyngeal cancer; OC, ovarian cancer; OS, osteosarcoma; OSCC, oral squamous cell carcinoma; RCC, renal cell carcinoma.