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. Author manuscript; available in PMC: 2022 Mar 10.
Published in final edited form as: J Control Release. 2021 Jan 12;331:164–175. doi: 10.1016/j.jconrel.2021.01.013

Fig. 3.

Fig. 3.

Induction of antigen-specific tolerance of EAE. (A) Antigen-specific immune tolerance induction via s.c. administration of MOG-PLGA-PEG-NPs. EAE mice were treated at the onset of disease and again 5 days later (MOG35–55 solution: n=7; OVA-PLGA-PEG-NPs: n=13; MOG-PLGA-PEG-NPs: n=12; MOG-PLGA-NPs: n=7). (B) Effects of injection timing on NP-induced immune tolerance (n=5~6). Data are represented as mean ± S.E.M. Statistics are shown for the last data point using two-way ANOVA with post-hoc Tukey test. **p<0.01; ***p<0.001.