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. 2020 Dec 18;49(5):e30. doi: 10.1093/nar/gkaa1213

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — D135T exhibited similar capacity as D135S to remove human tRNA modifications in tRNA-seq experiments. (A) Mutation rate in sequencing of HEK293T samples for tRNA^Arg(ACG) and tRNA^Arg(CCT) in samples of no enzyme, wild type AlkB (WT), wild type AlkB plus the D135S mutant, and wild type AlkB plus the D135T mutant. I34 has an A-to-G mutation signature under all circumstances and is not sensitive to AlkB treatment. (B) Heatmap showing mutation rates at m¹A58 for all cytosolic tRNAs under the four conditions in tRNA-seq. Mutation rates are shown for the highest expressed tRNA isodecoder among each isoacceptor family (27).