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. 2021 Feb 12;49(5):2946–2958. doi: 10.1093/nar/gkab075

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Structure of RBM45^RRM1–2−ssDNA complex. (A) The overall structure of the RBM45^RRM1–2−ssDNA complex. RBM45 is shown as green cartoon, the ssDNAs are shown as yellow sticks. The simulated annealing omit map of ssDNA (Fo − Fc contoured at 2.5 σ) are shown as gray meshes. (B) The surface electrostatic potential of RBM45^RRM1–2. The ssDNA bind to the positively charged regions. (C) Structural changes of RBM45^RRM1–2 by DNA-binding. The RBM45^RRM1–2 in complex and apo structures are shown as green and gray ribbons, respectively. The DNA is shown as yellow sticks. The changed regions are enclosed in red dashed circles. (D) Superimposition of RRM1 and RRM2. The RRM1 and RRM2 are shown as green and orange cartoons, respectively. The ssDNA bound RRM1 and RRM2 are shown as yellow and magenta sticks.