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. 2021 Feb 15;49(5):2777–2789. doi: 10.1093/nar/gkab073

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Structural comparison of Can2 with Can1. (A) Superimposition of CARF domain dimer from Can2 (cyan) bound to cA₄ (yellow) with the CARF domains of Can1 bound to cA₄ (PDB: 6SCE) (pink). The Can2 CARF domain dimer superimposes with the Can1 CARF domains with an RMSD of 2.6 Å over 256 Cα atoms. (B) Superimposition of nuclease domain from Can2 (blue) and Can1 (pink) (RMSD of 3.2 Å over 139 Cα atoms). (C) Superimposition cA₄ molecules bound to Can2 (yellow) and Can1 (pink) shown in stick representation (carbon in yellow/pink, oxygen in red, nitrogen in blue, phosphate in magenta; RMSD 3.1 Å over 88 atoms). Each AMP is numbered (A1-A4).