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. 2021 Feb 12;49(5):2859–2877. doi: 10.1093/nar/gkab065

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — SUMOylation of YTHDF2 increases its binding with m⁶A-mRNAs. (A) Cumulative frequency of the binding affinity with log₂-fold change in MeRIP + non-RIP targets (green) and MeRIP+RIP-targets (red) between YTHDF2-WT and YTHDF2-K⁵⁷¹R groups (Extended Data Supplementary Tables S1, S2). P values were calculated with a Kolmogorov-Smirnov test. (B, C) Cumulative distribution of mRNA log₂-fold changes between 2-D08 (treated with 2-D08) and control (Extended Data Supplementary Tables S1 and S3) (B), GA (treated with GA) and control (Extended Data Supplementary Tables S1 and S4) (C) for MeRIP+non-RIP targets (green) and MeRIP+RIP-targets (red). P values were calculated with a Kolmogorov–Smirnov test. (D) Distribution of genes with a significant change in both 2-D08 treated group and GA treated group compared to control for RIP+MeRIP targets in stable H1299 shYTHD2-WT cells (Extended Data Tables S1, S5 and S6).