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. 2021 Feb 8;49(5):2450–2459. doi: 10.1093/nar/gkab040

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — DNA methylation inhibits TDG-mediated chromatin condensation. (A) Precipitation assay to monitor nucleosome array oligomerization. (Un)methylated nucleosome arrays were incubated with the indicated concentration of TDG, oligomers were removed by centrifugation, and the percentage of arrays remaining in solution was determined by gel electrophoresis. (B) Soluble fraction following treatment of (un)methylated arrays with different TDG variants (1 μM). Error bars represent standard deviation from at least three independent experiments.