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Sequence alignment of HIN domains. These HIN domains are from representative human and murine PYHIN family proteins. The secondary structure components were labeled on the top of the alignment. Highly conserved residues are highlighted in yellow. Positively charged residues in L12 and L45 are coloured in red. The residues involved in binding DNA are in black boxes. The red dotted boxes show the residues speculated to be involved in DNA-binding in p204 HINa and HINb domains.
