Table 2.

Multivariate Cox proportional hazard regression analysis of 28-day mortality in the low APACHE-II score group

Variable	β	Hazard ratio (95% confidence interval)	p value
NGAL ≥ 511.5 ng/mL	0.878	2.405 (1.209–4.783)	0.012
APACHE-II score ≥ 23.5	0.829	2.291 (1.173–4.472)	0.015

Multivariate regression model was adjusted with parameters showing signif icant difference between the survivor and non-survivor groups. Parameters were as follows: NGAL group according to cutoff value (511.5 ng/mL), APACHE-II score group according to cutoff value (23.5), Sequential Organ Failure Assessment (SOFA) score group according to cutoff value (10.5), age, inotropic agent administration, and indication for continuous renal replacement therapy initiation (sepsis).

APACHE-II, Acute Physiology and Chronic Health Evaluation-II; NGAL, neutrophil gelatinase-associated lipocalin.