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. 2021 Jan 18;2021:5472605. doi: 10.1155/2021/5472605

Figure 5.

Figure 5

PTEN knockdown prevented hemorrhagic outcomes via suppressing neuronal autophagy. (a) Representative images of H&E and Nissl staining in the hippocampal CA1 region at 3 d post-ICH. Bar, 50 μm. (b) ELISA analysis of inflammatory cytokines TNF-α, IL-1β, and IL-6 in the damaged hippocampus. (c–e) The effects of CQ on hippocampus-dependent learning and memory were assessed in the MWM test, Y-maze test, and PAT test. (f) Representative bands and quantitative analysis of LC3, Beclin-1, and p62 in the ipsilateral hippocampus post-ICH. ∗P < 0.05 compared with the Sham group; #P < 0.05 compared with the ICH group.