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PTEN inhibition restricted FoxO3a dephosphorylation and nuclear translocation by the PI3K/AKT signaling. (a, b) Representative bands and quantitative analysis of p-AKT, AKT, p-FoxO3a FoxO3a, and nuclear/cytosolic FoxO3a in the ipsilateral hippocampus at 3 d post-ICH. Lamin was used as a nuclear fraction loading control. ∗P < 0.05 compared with the Sham group; #P < 0.05 compared with the ICH group.
