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. 2021 Mar 12;14(3):dmm046789. doi: 10.1242/dmm.046789

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© 2021. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Loss of Ezh2 in the Tbx1 expression domain causes severe thymic hypoplasia in E18.5 embryos. (A-D) Heart and thymus preparations from E18.5 embryos. Note the small thymus in Ezh2^cko embryos (arrows). (E) Section of an E18.5 control (Tbx1^Cre/+;Ezh2^flox/+) thymus stained with DAPI (blue for nuclei) and immunostained with an anti E-Cadherin (CDH1) antibody (red). (F) Section of an Ezh2^cko thymus at the same magnification as in E. An adjacent section is shown magnified in F′. Note the large number of CDH1-lined cysts, which are also present, but in a very small number, in control embryos (arrows).