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The activities of SQOR and ACADS both drive electrons into the mitochondrial Q pool, which restricts the capacity of sulfide oxidation during acute H2S exposures. As a countermeasure, SQOR can catalyze the formation of CoA-SSH, a tight-binding inhibitor of ACADs. Inhibition of ACADS by CoA-SSH relieves competition for the Q pool to prioritize sulfide oxidation.
