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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Pain. 2021 Apr 1;162(4):1116–1125. doi: 10.1097/j.pain.0000000000002116

Figure 6. Attenuation of LMWH hyperalgesia by HMWH.

Figure 6.

Male and female rats received HMWH (1 μg/5 μL) or vehicle (5 μL) intradermally, on the dorsum of the hind paw, 10 min after LMWH (1 μg/5 μL) was injected in the same site. Mechanical nociceptive threshold was evaluated over the 30 min after LMWH administration.

A. Male: HMWH significantly attenuated LMWH-induced hyperalgesia in males (F(1,10)=33.54, *p=0.0103, when the LMWH-induced hyperalgesia is compared between HMWH- and vehicle-treated groups 10 min after intradermal LMWH; **p=0.0040, when the LMWH-induced hyperalgesia is compared between HMWH- and vehicle-treated groups 15 and 30 min after intradermal LMWH; ***p=0.0001, when the LMWH-induced hyperalgesia is compared between HMWH- and vehicle-treated groups 20 min after intradermal LMWH; two-way repeated-measures ANOVA followed by Holm-Šídák multiple comparison test). n=6 paws per group.

B. Female: HMWH did not significantly attenuate LMWH-induced hyperalgesia in females (F(1,11)=0.6400, p=0.440, when the LMWH-induced hyperalgesia is compared between HMWH- and vehicle-treated groups after intradermal LMWH; two-way repeated-measures ANOVA followed by Holm-Šídák multiple comparison test). n=6 paws per group.