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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Pain. 2021 Apr 1;162(4):1126–1134. doi: 10.1097/j.pain.0000000000002110

Figure 4.

Figure 4.

Inhibition of colon epithelium reduces DSS-induced hypersensitivity. A) VMRs to 60 mmHg colorectal distension were recorded in DSS-treated Vil-Arch and control littermate mice before (Baseline) and during yellow light stimulation (+ Laser). B) Comparing the effects of yellow light in DSS-treated Vil-Arch vs. control mice, there was a significant interaction between genotype and laser (p = 0.005; two-way ANOVA; Fig. 4B). Yellow light significantly reduced the VMR in Vil-Arch mice [n = 5 (3 male, 2 female); p = 0.02; Holm-Sidak test] but did not reduce the VMR in control mice [n = 4 (1 male, 3 female); p = 0.11; Holm-Sidak test]. C) Yellow light produced effective inhibition in 4 out of 5 Vil-Arch mice. The mean of the baseline and the inhibited trials are shown. Inhibition occurred in 60% of CRD + laser trials (inset). D) Yellow light-induced inhibition in DSS-treated Vil-Arch mice (n = 4) was similar to inhibition in untreated Vil-Arch mice (n = 8; p = 0.15, Mann-Whitney test).