Table 1:
Demographic characteristics of the study populations including ILCCO OncoArray, UK Biobank and the National Lung Screening Trial (NLST)
| PRS construction | PRS validation Model performance evaluation | Projection in screen-eligible population | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ILCCO OncoArray (N=23,127) | UK Biobank (N=335,931) | NLST (N=50,772) | ||||||||||||
| Lung cancer cases | Controls | Lung cancer cases | Controls | Lung cancer cases | Controls | |||||||||
| Number | % | Number | % | Number | % | Number | % | Number | % | Number | % | |||
| Total | 13,119 | 10,008 | 1,768 | 334,163 | 1,986 | 48,786 | ||||||||
| Mean Age (SD) | 65.3 | (9.7) | 62.4 | (10.3) | 62.0 | (5.6) | 56.8 | (8.0) | 63.7 | (5.3) | 61.3 | (5.0) | ||
| Sex | ||||||||||||||
| Men | 8500 | (65) | 6494 | (65) | 921 | (52) | 154,571 | (46) | 1,195 | (60) | 28,748 | (59) | ||
| Women | 4619 | (35) | 3514 | (35) | 847 | (48) | 179,592 | (54) | 791 | (40) | 20,038 | (41) | ||
| Smoking | ||||||||||||||
| Never | 1,196 | (9) | 2,896 | (29) | 236 | (13) | 183,435 | (55) | 0 | 0 | ||||
| Former | 4,878 | (38) | 3,292 | (33) | 808 | (46) | 117,502 | (35) | 789 | (40) | 25,589 | (52) | ||
| Current | 6,857 | (53) | 3,286 | (33) | 724 | (41) | 33,226 | (10) | 1,197 | (60) | 23,197 | (48) | ||
| Family history of lung cancer among first degree relatives | ||||||||||||||
| No | 10,291 | (83) | 8,570 | (89) | 1323 | (77) | 286,297 | (87) | 1,460 | (74) | 38,100 | (78) | ||
| Yes | 2,153 | (17) | 1,042 | (11) | 387 | (23) | 42,153 | (13) | 526 | (26) | 10,686 | (22) | ||
| COPD history | ||||||||||||||
| No | 7,850 | (69) | 6,587 | (81) | 1581 | (90) | 328,465 | (98) | 1790 | (90) | 46,405 | (95) | ||
| Yes | 3,514 | (31) | 1,565 | (19) | 180 | (10) | 5,311 | (2) | 196 | (10) | 2,381 | (5) | ||
SD, standard deviation; COPD, Chronic Obstructive Pulmonary Disease.