Table 2:
PRS decile | Model building (OncoArray) | Validation (UK Biobank) | |||
---|---|---|---|---|---|
OR (95%CI)a | P-value | OR (95%CI)b | P-value | ||
0–10% | 1(Referent) | 1 (Referent) | |||
10–20% | 1.30 (1.15,1.46) | 1.39 ×10−5 | 1.31 (1.02, 1.68) | 3.54 ×10−2 | |
20–30% | 1.62 (1.44, 1.82) | 1.34 ×10−15 | 1.16 (0.90, 1.50) | 2.46 ×10−1 | |
30–40% | 1.58 (1.41, 1.78) | 1.94 ×10−14 | 1.57 (1.24, 2.00) | 2.07 ×10−4 | |
40–50% | 1.77 (1.57, 1.99) | 3.18 ×10−21 | 1.67 (1.32, 2.12) | 2.25 ×10−5 | |
50–60% | 2.01 (1.78, 2.26) | 1.12 ×10−30 | 1.56 (1.23, 1.98) | 2.92 ×10−4 | |
60–70% | 2.19 (1.94, 2.46) | 7.91 ×10−38 | 1.67 (1.32, 2.13) | 1.89 ×10−5 | |
70–80% | 2.38 (2.11, 2.69) | 1.07 ×10−45 | 1.69 (1.34, 2.15) | 1.27 ×10−5 | |
80–90% | 2.70 (2.39, 3.04) | 4.23 ×10−58 | 2.00 (1.60, 2.53) | 2.58 ×10−9 | |
90–100% | 3.52 (3.11, 3.98) | 7.34 ×10−88 | 2.39 (1.92, 3.00) | 1.80 ×10−14 | |
Trend p-value | 1.77 × 10−127 | 5.26 ×10−20 |
adjusted for age, sex and top 5 principal components
adjusted for age, sex and top 5 principal components