Table 2:

The odds ratio and 95% confidence intervals of the PRS and lung cancer risk by decile in OncoArray and UK Biobank

PRS decile	Model building (OncoArray)			Validation (UK Biobank)
	OR (95%CI)a	P-value		OR (95%CI)b	P-value
0–10%	1(Referent)			1 (Referent)
10–20%	1.30 (1.15,1.46)	1.39 ×10−5		1.31 (1.02, 1.68)	3.54 ×10−2
20–30%	1.62 (1.44, 1.82)	1.34 ×10−15		1.16 (0.90, 1.50)	2.46 ×10−1
30–40%	1.58 (1.41, 1.78)	1.94 ×10−14		1.57 (1.24, 2.00)	2.07 ×10−4
40–50%	1.77 (1.57, 1.99)	3.18 ×10−21		1.67 (1.32, 2.12)	2.25 ×10−5
50–60%	2.01 (1.78, 2.26)	1.12 ×10−30		1.56 (1.23, 1.98)	2.92 ×10−4
60–70%	2.19 (1.94, 2.46)	7.91 ×10−38		1.67 (1.32, 2.13)	1.89 ×10−5
70–80%	2.38 (2.11, 2.69)	1.07 ×10−45		1.69 (1.34, 2.15)	1.27 ×10−5
80–90%	2.70 (2.39, 3.04)	4.23 ×10−58		2.00 (1.60, 2.53)	2.58 ×10−9
90–100%	3.52 (3.11, 3.98)	7.34 ×10−88		2.39 (1.92, 3.00)	1.80 ×10−14
Trend p-value		1.77 × 10−127			5.26 ×10−20

^a,adjusted for age, sex and top 5 principal components

^b,adjusted for age, sex and top 5 principal components