Skip to main content
. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Pharmacol Ther. 2020 Oct 24;220:107715. doi: 10.1016/j.pharmthera.2020.107715

Fig. 3.

Fig. 3.

Three major subclasses of circRNAs. (A) Exonic circRNAs (ecircRNAs) consist of only exon(s) (usually less than five) and represent the most important group of circRNA class. EcircRNAs have cytoplasmatic location and may regulate microRNA and protein functions.(B) Exon-intron circRNAs (EIciRNAs) are composed of exons and retained introns. EIciRNAs have nuclear localization and have been found to be able to regulate gene transcription in cis and probably also in trans.(C) Intronic circRNAs (ciRNAs) are derived from intron lariats and are accumulated in the nucleus in which regulate gene transcription in cis.