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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Pharmacol Ther. 2020 Oct 24;220:107715. doi: 10.1016/j.pharmthera.2020.107715

Table 4B.

Anti-inflammatory circRNAs. Different circRNAs that attenuates vascular inflammation and cardiovascular diseases. Abbreviation: HUVEC: human umbilical vein endothelial cells; AS: atherosclerosis; VSMCs: vascular smooth muscle cells; Mø: macrophages; HAECs: human aortic endothelial cells; Ox-LDL: oxidized low-density lipoprotein; TNF-α: tumor necrosis factor-alpha;

CircRNA name Expression of circRNAs Cells/tissue Function Mechanism/Target Pathways PMID
hsa_circRNA-00 54633 Upregulated in high glucose conditions HUVEC Decreased the high glucose-induced endothelial cell dysfunction, including proliferation, migration and promote angiopoiesis microRNA-218 microRNA-218/heme oxygenase-1 axes 29693114
CircANRIL Downregulated in AS VSMCs/Mø Atheroprotection against human AS Binds to PES1, thereby impairing pre-rRNA processing and ribosome biogenesis - 27539542
Circ_0003204 Upregulated by ox-LDL and in cerebral AS HAECs Inhibits proliferation, migration and tube formation of ECs in AS miR-370 miR-370–3p/TGFβR2/phosph-SMAD3 pathway 31900142
Circ-Sirt1 Downregulated by TNF-α stimulation and in neointima hyperplasia VSMCs Inhibits inflammatory phenotypic switching of VSMCs miR-132/212 circ-Sirt1/miR-132/212/NF-κB pathway 30820544