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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Ann Neurol. 2021 Jan 21;89(4):726–739. doi: 10.1002/ana.26015

Figure 3 – Increased tuber burden, but not tuber location, is associated with infantile spasms.

Figure 3 –

Binary tuber distribution masks were summed for: all children with TSC (A), the cohort of children with infantile spasms (B), and the cohort of children without infantile spasms (C). Both visual comparison and quantitative spatial analysis (D), did not identify a particular pattern for tuber distribution in general, nor that distinguished between children with and without a history of infantile spasms. While overall tuber burden was statistically different between the two cohorts (E), there was not a statistically significant difference between cortical lobe involvement (F).