Figure 5 – Lesion network connectivity with the bilateral globus pallidus and cerebellar vermis predicts locations where tubers are more likely to cause infantile spasms.

The intersection of connectivity with the globus pallidi (Gpi, blue shading) and connectivity with the cerebellar vermis (red shading) defined a specific network of areas (purple shading) predicted to be highly likely to cause infantile spasms if lesioned (A). As a demonstration, the same four patients shown in Figure 2, two with infantile spasms and two without infantile spasms, and with either high or low tuber burden, are again shown here with tuber burden (in red) compared to the identified network (in purple) (B and C). Among patients with infantile spasms (B), it can be seen that tubers are more likely to overlap with the predicted network (blue circles). Conversely, among patients without infantile spasms (C), tubers largely do not overlap with the predicted network.