Effect of genetically manipulating CPSs in rice cultivar Kitaake on susceptibility to Xanthomonas oryzae pathovar oryzae (Xoo). Histograms indicating Xoo colony forming units found in infected leaves from (A) wild-type (WT), cps2 and cps4, or (B) WT and cps2×4, or (C) WT, CPS2-OE and CPS4-OE. The data are means ± SD of nine individual replicates, error bars indicate standard deviation. Asterisks represent significant differences derived from one-way ANOVA followed by Dunnett’s multiple comparisons tests for A and C, unpaired two tailed Student’s t-test for B to compare the different lines against the wildtype (***P < 0.001, ****P < 0.0001). Three independent experiments were performed with similar results.