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. 2020 Jul 13;478(2):319–326. doi: 10.1007/s00428-020-02889-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A representative case of undifferentiated carcinoma of the pancreas with osteoclast-like giant cells, with an associated ductal adenocarcinoma, is shown. a Hematoxylin-eosin staining reveals an undifferentiated carcinoma with atypical cells and the presence of multinucleated osteoclast-like giant cells; neoplastic glands of the associated ductal adenocarcinoma are also evident (original magnification: × 20). b Snai2 is expressed by undifferentiated neoplastic cells, while neoplastic glands are totally negative (original magnification: × 20). c Twist1 is expressed by undifferentiated neoplastic cells, while neoplastic glands are totally negative (original magnification: × 20). d E-cadherin expression is lost by undifferentiated neoplastic cells, while it is retained by neoplastic glands (original magnification: × 20)