Figure 1.

Activation of different type of programmed cell neutrophil death, pathways by neutrophil senses external signals through its PRRs, and triggers effector functions. Neutrophils present in their cellular membrane, a great variety of receptors (pattern recognition receptors, PRR) that are capable of sensoring diverse MAMP (microorganisms associated molecular patterns) and DAMPs (damage-associated molecular patterns). Depending on the nature and intensity of the stimulus received, PRRs are capable of initiating signaling cascades that generally terminate in processes of cell death. These are mainly initiated by proinflammatory proteins, which possess effector functions that lead to the death of neutrophils by means of different mechanisms, such as NETosis, autophagy, necroptosis, or pyroptosis, among others. The receptor that is activated in the processes of cell death is very important, defining as it does the form of cell death that the cell takes. The processes of cell death generally begin with the receptor itself. However, the signaling cascade defines at some point what the fate of the neutrophil will be.