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Sensor proteins and signal cell death in distinct mechanisms of cell death of neutrophils.
| Apoptosis | Necrosis | Necroptosis | Pyroptosis | NETosis |
|---|---|---|---|---|
| Caspase−2,−3,−6,−7,−8,−9,−10 | HIF | RIPK1 | Caspase−1,−11 | Platelet-neutrophil interaction |
| Mitochondrial [Ca2+] uptake | Nutrients | RIPK3 | Inflammasome | |
| PIDDosome | Temperature | MLKL | ||
| Cythocrome C, ROS | Mechanical stress | NADPH oxidase (via NETosis) | ||
| Bacteria |
