Table 1.

Clinicopathological characteristics

n = 110
	n/median	%/min-max
Age, years	67.0	45–82
Gender
Male	58	52.7
Female	52	47.3
T-stage
pT1	3	2.7
pT2	22	20.0
pT3	81	73.6
pT4	4	3.6
N-stage
pN0	32	29.1
pN1	78	70.9
Stage
IA	3	2.7
IB	7	6.4
IIA	20	18.2
IIB	73	66.4
III	3	2.7
IV	4	3.6
Histological grade
1	30	27.3
2	65	59.1
3	7	6.4
Perineural invasion
Positive	36	34.6
Negative	68	65.4
PD-L1 in tumour cellsa
Positive	5	4.5
Negative	105	95.5
CD73+ tumour cell scoreb
High	37	33.6
Low	73	66.4
CD73+ TILsc
Positive	55	53.9
Negative	47	46.1
CD73+ stromad
Strong	38	34.5
Moderate	37	33.6
Weak	35	31.8
CD73+ vesselse
High	68	61.8
Low	42	38.2

^aTumour samples were considered PD-L1 positive when > 1% of the tumour cells were positive for PD-L1

^bThe score (0–300) was formed by multiplying the proportion of stained tumour cells by the staining intensity (0–3). 90 was set as a cut off value

^cTumour samples were considered positive when >3% of lymphocytes were positive for CD73

^dTumour stroma positivity was considered weak, moderate or strong when < 5%, 5–16% or > 17% of the stromal area was stained, respectively

^eDue to the strong staining intensity of vascular structures, 95% was set as a cut off value for CD73 positivity of vascular structures