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. 2021 Mar 17;11:6139. doi: 10.1038/s41598-021-85668-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Associations of the eight selected biomarkers, categorized as quartiles, with poor self-rated health. Odds ratios (ORs) and 95% confidence intervals (CIs) are from the logistic regression models, adjusted for age and gender. The “best” biomarker quartile was used as reference category. (A–H): C-reactive protein (CRP), high-density lipoprotein (HDL) cholesterol, haemoglobin A1C (HBA1C), 25-hydroxyl-vitamin-D (25-OH-vitaminD), zeaxanthin, apolipoprotein-B (Apo-B), cell-free DNA (cf-DNA) and protein carbonyls, respectively. The biomarkers were selected as examples of replicated and new associations representing different biological domains.