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. 2021 Mar 17;11:6132. doi: 10.1038/s41598-021-85137-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gene expression profiles in progressive and de novo MIBC samples. (A) Heat map displaying the 50 most differently expressed genes between progressive and de novo MIBC samples. Red pixels correspond to an increased abundance of mRNA in the samples, whereas green pixels indicate decreased mRNA levels. Rows represent genes and columns represent experimental samples. (B) Gene set enrichment analysis (GSEA) shows positive correlation of overexpressed genes in pathways involved in tumor progression.