Table 2.

Significant DEGs between progressive and de novo MIBC of validation phase (RT-qPCR) and comparison with fold change in genes from the discovery phase (Microarray).

Gene	Source	Validation phase		Discovery phase
		FDR	Fold change	p-Value	Fold change
ABCC9	Microarray	0.04	3.41	< 0.001	4.10
ARL5A	Microarray	0.001	1.49	0.001	2.47
CALD1	Microarray	< 0.001	3.34	< 0.001	3.90
FLNC	Microarray	< 0.001	4.48	0.001	4.83
GEM	Microarray	0.004	3.13	0.003	3.06
HIF1A	Microarray	< 0.001	1.99	< 0.001	3.30
RGS2	Microarray	0.001	4.54	< 0.001	4.25
SMAD5	Microarray	0.001	1.84	< 0.001	2.82
USP42	Microarray	0.001	2.23	< 0.001	− 5.30
ITGA5	Microarray	< 0.001	3.68	< 0.001	4.26
CD44	Literature	< 0.001	2.98	0.071	− 1.48
PDCD1LG2	Literature	0.004	2.26	0.814	1.09
IDO1	Literature	0.02	2.31	0.579	− 1.16
PGM5	Literature	< 0.001	5.40	0.308	1.57
DES	Literature	< 0.001	7.68	0.779	1.16
C7	Literature	< 0.001	4.77	0.067	2.09
SFRP4	Literature	< 0.001	5.28	0.119	2.45
COMP	Literature	< 0.001	3.60	0.752	1.21
ZEB1	Literature	< 0.001	3.33	0.071	1.59
ZEB2	Literature	< 0.001	2.83	0.210	1.32
TWIST1	Literature	0.003	8.22	0.886	1.04
MSN	Literature	0.001	1.94	0.834	− 1.07
NR3C1	Literature	0.001	1.97	0.330	1.21
CTSE	Literature	0.007	2.35	0.238	1.66

The source from what the gene was taken (microarray/literature) is also shown.

FDR False Discovery Rate.