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. 2021 Mar 4;7:583360. doi: 10.3389/fcvm.2020.583360

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Copyright © 2021 Morales, Herrington, Bacha, Morell, Prodán, Mroczek, Sivalingam, Cox, Bennink and Asch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Artistic impression of intended endogenous tissue restoration process at implant (Top) and microstructural level (Bottom). The porous implant is functional upon placement and gets permeated with blood components including red and white blood cells and platelets. Subsequently, macrophages are recruited as part of the host-material response. Macrophages governing tissue remodeling by recruiting other cells including (myo)fibroblasts and endothelials cells and govern implant absorption by secreting oxygen radicals, eventually resulting in a functionally restored natural implant.