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. 2021 Mar 4;8:656086. doi: 10.3389/fmed.2021.656086

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Copyright © 2021 Xu, Liu, Li, Ye, Zha, Li, Zhao, Pu, Bao, Chen, Yu and Pei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quercetin reversed GF-triggered aerobic glycolysis in glomerular MCs. (A) Levels of pH in each group. (B) Levels of lac in each group. (C) Activity of PFK tested by Colorimetric Assay. (D) Western blot analysis showing phosphorylation levels of PKM2 in each group. As expect, these GF-triggered increase of aerobic glycolysis could be dose-dependently blocked by quercetin and glycolytic pathway inhibitor 2-deoxyglucose (2-DG). The error bar reflects the S.E.M. of at least three independent experiments.