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. 2021 Mar 4;8:656086. doi: 10.3389/fmed.2021.656086

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Copyright © 2021 Xu, Liu, Li, Ye, Zha, Li, Zhao, Pu, Bao, Chen, Yu and Pei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quercetin alleviated GF-induced alteration of ISCU1/2 levels in MCs. (A) Representative IF staining for ISCU1/2 in MCs under different glucose. Blue indicates DAPI staining and grean means ISCU1/2 staining. Scale bar = 50 μm. (B) Western blot analysis showing protein levels of ISCU1/2. (C) Silence effect of ISCU siRNA tested by RT-qPCR. (D) Activities of FeS-dependent metabolic enzymes (aconitase and complex I) measured by colorimetric assays. (E) Viability of MCs tested by CCK8. (F) The effects of quercetin and ISCU1/2 siRNA on Inflammation levels of TNFα and IL-1β in MCs under different glucose. (G,H) The effects of quercetin and ISCU1/2 siRNA on index of apoptosis and activity of caspase-3 in MCs. (I) Effects of quercetin and ISCU1/2 siRNA on aerobic glycolysis activity (levels of pH, lac, and PFK). The error bar reflects the S.E.M. of at least three independent experiments.