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. 2021 Mar 4;8:656086. doi: 10.3389/fmed.2021.656086

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Copyright © 2021 Xu, Liu, Li, Ye, Zha, Li, Zhao, Pu, Bao, Chen, Yu and Pei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quercetin inhibited GF-induced upregulation of HIF-1α/miR-210 levels. (A,B) mRNA expression and protein contents of HIF-1α measured by RT-qPCR and WB, respectively. (C) RT-qPCR analysis presented expression of miR-210. (D) Western blot analysis showing levels of ISCU1/2. (E) Cell viability tested by CCK8. (F) Levels of inflammation factors. (G,H) The effects of quercetin and miR-210 mimic on index of apoptosis and activity of caspase-3 in MCs. (I) Effects of quercetin and miR-210 mimic on aerobic glycolysis activity (levels of pH, lac, and PFK). The error bar reflects the S.E.M. of at least three independent experiments.