Figure 6.

Increased central to peripheral memory cell gradient in diabetic mice. (A) Gating strategy for identification of CD44 and CD62L within CD4⁺ and CD8⁺ cells in the BM, spleen, and peripheral blood of wt/db and db/db mice. Reported frequencies are illustrative of a representative case for each group. (B) Relative frequency of CD44⁻CD62L^high population within CD4⁺ cells. (C) Relative frequency of CD44⁻CD62L^high population within CD8⁺ cells. (D) Relative frequency of CD44^highCD62L^high population within CD4⁺ cells. (E) Relative frequency of CD44^highCD62L^high population within CD8⁺ cells. (F) Relative frequency of CD44^highCD62L⁻ population within CD4⁺ cells. (G) Relative frequency of CD44^highCD62L⁻ population within CD8⁺ cells. Values are mean ± SEM, with each point representing an individual case. (H) Radar graph of modulated cytokine in BM of db/db mice. Measurements performed in a pool of four mice per group. (I) STRING network of modulated factors.