Figure 8.

Effect of abatacept on naïve and memory T cells of T2D mice. (A) Gating strategy for identification of CD44⁺ and CD62L⁺ within CD4⁺ and CD8⁺ fractions in the BM, spleen, and peripheral blood of db/db mice given vehicle or abatacept. Reported frequencies are illustrative of a representative case for each group. (B) Relative frequency of naïve cells within CD4⁺ cells. (C) Relative frequency of naïve cells within CD8⁺ cells. (D) Relative frequency of TEM cells within CD4⁺ cells. (E) Relative frequency of TEM cells within CD8⁺ cells. (F) Relative frequency of TCM cells within CD4⁺ cells. (G) Relative frequency of TCM cells within CD8⁺ cells. Values are mean ± SEM, with each point representing an individual case.