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. 2021 Mar 4;9:619549. doi: 10.3389/fcell.2021.619549

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Copyright © 2021 Feng, Li, Lou, Ma, Wu and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development of the DNA replication-related signature. (A) Cross-validation for tuning parameter (lambda) screening in the LASSO regression model. (B) LASSO coefficient profiles of 20 prognostic DNA replication-related genes. (C) Forest plot of the seven DNA replication-related genes. (D) Survival cure for EREG. (E) Survival cure for KCTD13. (F) Survival cure for MCM3AP. (G) Survival cure for MCM7. (H) Survival cure for POLG2. (I) Survival cure for TERF2. (J) Survival cure for TP73. ^∗p < 0.05; ^∗∗p < 0.01; ^∗∗∗p < 0.001.