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. 2021 Mar 4;9:561086. doi: 10.3389/fcell.2021.561086

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Copyright © 2021 Findeiss, Schwarz, Evsyukov, Rösler, Höllerhage, Chakroun, Nykänen, Shen, Wurst, Kohl, Tost and Höglinger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miRNome-wide screen and overlap analysis with transcriptome data. (A) Volcano plot shows 796 detected miRNAs in SNCA vs. GFP overexpressing LUHMES neurons 4 days after adenoviral transduction. 55 miRNAs with P < 0.05 and 23 with P < 0.01 were differentially expressed (non-adjusted p-value). (B) Identification of 154 overlap genes of predicted miRNA target genes (TargetScan 7.2 database) and experimentally validated target genes (MiRTarBase 7.0 database) with miRNAs of P < 0.01, and significantly regulated mRNAs (P_adj < 0.05; Benjamini–Hochberg FDR) from transcriptome analysis (BeadChip). (C) Overrepresented biological processes identified by PANTHER GO-Slim pathway analysis among 154 overlap genes.