Table 2.
Amikacin susceptibility and rrs mutations in MAC and M. abscessus clinical isolates.
| Species | Amikacin MIC (µg/ml) | No. of isolates | No. of isolates with rrs mutation at the specified positionsa | ||||||
|---|---|---|---|---|---|---|---|---|---|
| None | A1408G | C1409T | G1491C | G1491T | C1496T | T1498A | |||
| MAC (n = 54) | 64 | 23 | 20 | 1 | 0 | 1 | 0 | 1 | 0 |
| 128 | 5 | 0 | 3 | 0 | 1 | 0 | 1 | 0 | |
| 256 | 3 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | |
| > 256 | 23 | 0 | 21 | 0 | 1 | 1 | 0 | 0 | |
| M. abscessus (n = 8) | 64 | 3 | 0 | 0 | 3 | 0 | 0 | 0 | 0 |
| 128 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 256 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | |
| > 256 | 4 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | |
| Total | 62 | 20 | 29 | 5 | 3 | 2 | 2 | 1 | |
MAC M. avium complex, MIC minimum inhibitory concentration.
aEscherichia coli numbering.