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. 2021 Mar 17;12(4):282. doi: 10.1038/s41419-021-03556-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A MicroRNA sequencing indicated that miR-34a, which was predicted to target the 3′UTR of CD47/PD-L1, was upregulated significantly after LSD1 knockdown in SiHa cells. B Changes in miR-34a expression after LSD1 knockdown in SiHa cells were confirmed by qRT-PCR (n = 3 per group). C, D Changes in the expression of PD-L1/CD47 mRNA in SiHa and C33A cells after transfection with miR-34a mimics or inhibitors (n = 3 per group). E Western blotting and F flow cytometry showed that miR-34a mimics upregulated the protein expression of CD47/PD-L1 in SiHa and C33A cells, whereas miR-34a inhibitors had the opposite effects. Each experiment was repeated three times. N.S. not significant. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.